Bioactive Pigments of Monascus purpureus Attributed to Antioxidant, HMG-CoA Reductase Inhibition and Anti-atherogenic Functions

Monascus purpureus is known to produce pigment molecules. The pigments were extracted from M. fermented rice. In-vitro antioxidant effects of observed and presumed alleviate oxidative stress related atherosclerosis effect in rats fed with high fat diet (HFD) for 14 weeks. formation lipid peroxide due the oxidation serum was higher HFD. While, feeding rice (groups III-V) significantly lowered (27.1–51.7%) rats, indicated antioxidative pigments. In addition, cholesterol triacylglycerol by 44.82 45.30%, respectively. Whereas, LDL-cholesterol levels decreased 70.12% HDL-cholesterol increased 34.58%. atherogenic indices (LDL/HDL TC/HDL) reduced 77.80 61.05%, respectively, These data confirmed anti-atherosclerotic Further liver enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase activity inhibited up 54%. identification statins, sterols fatty acids revealed HMG-CoA inhibitory activity. This synthesis lower Accordingly antioxidant, inhibition reductase, anti-atherogenic functions attributed collective bioactive metabolites.